Vaginal and cervical cancers and other abnormalities associated with exposure in utero to diethylstilbestrol and related synthetic hormones.

The National Cancer Institute is supporting a study of vaginal cancer and other noncancemous genital tract innegu lamitiesin offspring of mothers who received synthetic estro gens during pregnancy. The study, entitled The DESAD Project (DES7 and Adenosis), seeks to provide answers concerning the risk to exposed offspring born after 1940 of developing cancer on other medically important conditions, including vaginal adenosis and cervical abnormalities. Each of 4 participating institutions8 is identifying 500 or more subjects with documented in utero exposure. Exposed daughters of different ages are being examined and fol lowod to determine incidence and natural history of vaginal adenosis and other irregularities.